Bioanalytical facility

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Assessing the quality of tools used in disease control (prevention and treatment). Tools of prevention include insecticides on fabrics, sprayed on walls. Treatment include medicines, eye drops and, potentially, vaccines.

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Who we are

Harparkash Kaur set up the bioanalytical facility as part of the Gates Malaria Partnership in 2001, and from 2008 was lead investigator on the drug quality project for the ACT Consortium.

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About bioanalytical facility

Assessing the quality of tools used in disease control (prevention and treatment)

Prevention: Tools of prevention include insecticides on fabrics, sprayed on walls. We use high performance liquid chromatography –photo diode array (HPLC-PDA) detection methods to quantitatively measure the amounts of insecticides i.e. type 2-pyrethroids (detlamathrin, alpha-cypermethrin, lambda-cyhalothrin), permethrin, chlorfenapyr, DDT etc.

We have also developed a semi-quantitative test kit for use on the ground to measure type 2-pyrethroids, in the absence of analytical laboratories with HPLC-PDA technologies.

Treatment: Methodology quantitatively measuring all antimalarials (past and present) and their metabolites, as well as antibiotics, antiretroviral and antihypertensive medicines. We routinely analyse using HPLC-PDA to authenticate an antifibrinolytic, tranexamic acid, a medication used to treat or prevent excessive blood loss deployed in the CRASH and HALT-IT trials.

We have also developed a semi-quantitative test kit for use on the ground to measure the artemisinin derivative component of the first line antimalarial medicines.

The facility builds on the work of the ACT Consortium from 2008-2016

Physicochemical assessment of drugs is highly informative and in vitro dissolution testing is carried out in our laboratory following the pharmacopeia-authorised monograph prior to the start of the clinical trials. This offers information of the in vivo bioavailability and bioequivalence of oral solid dosage forms.

Publications

Publications List

Wilson, B.K. ; KAUR, H. ; Allan, E.L. ; Lozama, A. ; Bell, D. (2017)

The American journal of tropical medicine and hygiene. ISSN 0002-9637 DOI: 10.4269/ajtmh.16-0904

Sutherland, CJ; Lansdell, P; Sanders, M; Muwanguzi, J; van Schalkwyk, DA; Kaur, H; Nolder, D; Tucker, J; Bennett, HM; Otto, TD; Berriman, M; Patel, TA; Lynn, R; Gkrania-Klotsas, E; Chiodini, PL (2017)

Antimicrobial agents and chemotherapy. ISSN 0066-4804 DOI: 10.1128/AAC.02382-16

Hall, Z; Allan, EL; van Schalkwyk, DA; van Wyk, A; Kaur, H (2016)

The American journal of tropical medicine and hygiene, 94 (5). pp. 993-1001. ISSN 0002-9637 DOI: 10.4269/ajtmh.15-0665

Hodel, EM; Kaur, H; Terlouw, DJ (2016)

The American journal of tropical medicine and hygiene. ISSN 0002-9637 DOI: 10.4269/ajtmh.16-0759

Redfern, J; Adedoyin, RA; Ofori, S; Anchala, R; Ajay, VS; de Andrade, L; Zelaya, J; Kaur, H; Balabanova, D; Sani, MU (2016)

BMJ Global Health, 1 (2)

Tivura, M; Asante, I; van Wyk, A; Gyaase, S; Malik, N; Mahama, E; Hostetler, DM; Fernandez, FM; Asante, KP; Kaur, H; Owusu-Agyei, S (2016)

BMC Pharmacol Toxicol, 17 (1). p. 48. ISSN 2050-6511 DOI: 10.1186/s40360-016-0089-2

Orsborne, J; DeRaedt Banks, S; Hendy, A; Gezan, SA; Kaur, H; Wilder-Smith, A; Lindsay, SW; Logan, JG (2016)

PLoS One, 11 (5). e0152805. ISSN 1932-6203 DOI: 10.1371/journal.pone.0152805

Kaur, H; Clarke, S; Lalani, M; Phanouvong, S; Guérin, P; McLoughlin, A; Wilson, BK; Deats, M; Plançon, A; Hopkins, H; Miranda, D; Schellenberg, D (2016)

Malar J, 15 (1). p. 86. ISSN 1475-2875 DOI: 10.1186/s12936-016-1096-x

Tabernero, P; Mayxay, M; Culzoni, MJ; Dwivedi, P; Swamidoss, I; Allan, EL; Khanthavong, M; Phonlavong, C; Vilayhong, C; Yeuchaixiong, S; Sichanh, C; Sengaloundeth, S; Kaur, H; Fernández, FM; Green, MD; Newton, PN; (2015)

The American journal of tropical medicine and hygiene, 92 (6 Suppl). pp. 95-104. ISSN 0002-9637 DOI: 10.4269/ajtmh.15-0057

ACT Consortium Drug Quality Project Team and the IMPACT2 Study T; (2015)

The American journal of tropical medicine and hygiene, 92 (6 Suppl). pp. 75-86. ISSN 0002-9637 DOI: 10.4269/ajtmh.14-0544

Kaur, H; Seifert, K; Hawkes, GE; Coumbarides, GS; Alvar, J; Croft, SL; (2015)

The American journal of tropical medicine and hygiene, 92 (6 Suppl). pp. 31-8. ISSN 0002-9637 DOI: 10.4269/ajtmh.14-0586

Fadeyi, I; Lalani, M; Mailk, N; Van Wyk, A; Kaur, H; (2015)

The American journal of tropical medicine and hygiene, 92 (6 Suppl). pp. 87-94. ISSN 0002-9637 DOI: 10.4269/ajtmh.14-0539

Lalani, M; Kaur, H; Mohammed, N; Mailk, N; van Wyk, A; Jan, S; Kakar, RM; Mojadidi, MK; Leslie, T; (2015)

The American journal of tropical medicine and hygiene, 92 (6 Suppl). pp. 51-8. ISSN 0002-9637 DOI: 10.4269/ajtmh.14-0394

Yeung, S; Lawford, HL; Tabernero, P; Nguon, C; van Wyk, A; Malik, N; DeSousa, M; Rada, O; Boravann, M; Dwivedi, P; Hostetler, DM; Swamidoss, I; Green, MD; Fernandez, FM; Kaur, H; (2015)

The American journal of tropical medicine and hygiene, 92 (6 Suppl). pp. 39-50. ISSN 0002-9637 DOI: 10.4269/ajtmh.14-0391

Pinder, M; Jawara, M; Jarju, LB; Salami, K; Jeffries, D; Adiamoh, M; Bojang, K; Correa, S; Kandeh, B; Kaur, H; Conway, DJ; D'Alessandro, U; Lindsay, SW; (2015)

Lancet, 385 (9976). pp. 1436-46. ISSN 0140-6736 DOI: 10.1016/S0140-6736(14)61007-2

DeRaedt Banks, S; Orsborne, J; Gezan, SA; Kaur, H; Wilder-Smith, A; Lindsey, SW; Logan, JG; (2015)

PLoS neglected tropical diseases, 9 (10). e0004109. ISSN 1935-2727 DOI: 10.1371/journal.pntd.0004109

Kaur, H; Allan, EL; Mamadu, I; Hall, Z; Ibe, O; El Sherbiny, M; Wyk, Av; Yeung, S; Swamidoss, I; Green, MD; Dwivedi, P; Culzoni, MJ; Clarke, S; Schellenberg, D; Fernández, FM; Onwujekwe, O; (2015)

PLoS One, 10 (5). e0125577. ISSN 1932-6203 DOI: 10.1371/journal.pone.0125577

Visser, BJ; Meerveld-Gerrits, J; Kroon, D; Mougoula, J; Vingerling, R; Bache, E; Boersma, J; van Vugt, M; Agnandji, ST; Kaur, H; Grobusch, MP; (2015)

Malar J, 14 (1). p. 273. ISSN 1475-2875 DOI: 10.1186/s12936-015-0795-z

Tungu, PK; Malima, R; Mosha, FW; Lyimo, I; Maxwell, C; Kaur, H; Kisinza, WN; Magesa, SM; Kirby, MJ; Rowland, M; (2015)

Malar J, 14 (1). p. 225. ISSN 1475-2875 DOI: 10.1186/s12936-015-0742-z

Kaur, H; (2015)

In: Walport, Mark, (ed.) Annual Report of the Government Chief Scientific Adviser 2015: Forensic Science and Beyond: Authenticity, Provenance and Assurance Evidence and Case Studies. Government Office for Science, London, pp. 132-7.

Russell, TL; Morgan, JC; Ismail, H; Kaur, H; Eggelte, T; Oladepo, F; Amon, J; Hemingway, J; Iata, H; Paine, MJI; (2014)

Malaria Journal, 13. p. 178. ISSN 1475-2875 DOI: 10.1186/1475-2875-13-178

Kitau, J; Oxborough, R; Kaye, A; Chen-Hussey, V; Isaacs, E; Matowo, J; Kaur, H; Magesa, SM; Mosha, F; Rowland, M; Logan, J; (2014)

Parasit Vectors, 7 (1). p. 129. ISSN 1756-3305 DOI: 10.1186/1756-3305-7-129

Beshir, KB; Sutherland, CJ; Sawa, P; Drakeley, CJ; Okell, L; Mweresa, CK; Omar, SA; Shekalaghe, SA; Kaur, H; Ndaro, A; Chilongola, J; Schallig, HD; Sauerwein, RW; Hallett, RL; Bousema, T; (2013)

The Journal of infectious diseases, 208 (12). pp. 2017-24. ISSN 0022-1899 DOI: 10.1093/infdis/jit431

Chijioke-Nwauche, I; van Wyk, A; Nwauche, C; Beshir, KB; Kaur, H; Sutherland, CJ; (2013)

Antimicrobial agents and chemotherapy, 57 (9). pp. 4146-50. ISSN 0066-4804 DOI: 10.1128/AAC.02508-12

Malima, R; Tungu, PK; Mwingira, V; Maxwell, C; Magesa, SM; Kaur, H; Kirby, MJ; Rowland, M; (2013)

Parasit Vectors, 6 (1). p. 296. ISSN 1756-3305 DOI: 10.1186/1756-3305-6-296

Kaur, H; Long, J; van Wyk, A; Malik, N; Mamadu, I; Allan, L; Yeung, S; Fadei, I; Green, M; Fernandez, F; (2013)

Dwivedi, P; Fernandez, F; Kaur, H; (2013)

Pearce, RJ; Ord, R; Kaur, H; Lupala, C; Schellenberg, J; Shirima, K; Manzi, F; Alonso, P; Tanner, M; Mshinda, H; Roper, C; Schellenberg, D; (2013)

The Journal of infectious diseases, 207 (5). pp. 848-59. ISSN 0022-1899 DOI: 10.1093/infdis/jis742

Picado, A; Singh, SP; Vanlerberghe, V; Uranw, S; Ostyn, B; Kaur, H; Das, ML; Sundar, S; Rijal, S; Tungu, P; Boelaert, M; Rowland, M; (2012)

Transactions of the Royal Society of Tropical Medicine and Hygiene, 106 (3). pp. 150-9. ISSN 0035-9203 DOI: 10.1016/j.trstmh.2011.10.014

Chaccour, CJ; Kaur, H; Mabey, D; Del Pozo, JL; (2012)

Lancet, 380 (9847). p. 1120. ISSN 0140-6736 DOI: 10.1016/S0140-6736(12)60649-7

Fernandez, FM; Hostetler, D; Powell, K; Kaur, H; Green, MD; Mildenhall, DC; Newton, PN; (2011)

The Analyst, 136 (15). pp. 3073-3082. ISSN 0003-2654 DOI: 10.1039/c0an00627k

Newton, PN; Green, MD; Mildenhall, DC; Plancon, A; Nettey, H; Nyadong, L; Hostetler, DM; Swamidoss, I; Harris, GA; Powell, K; Timmermans, AE; Amin, AA; Opuni, SK; Barbereau, S; Faurant, C; Soong, RCW; Faure, K; Thevanayagam, J; Fernandes, P; Kaur, H; Angus, B; Stepniewska, K; Guerin, PJ; Fernandez, FM; (2011)

Malaria Journal, 10. p. 352. ISSN 1475-2875 DOI: 10.1186/1475-2875-10-352

de Souza, JB; Okomo, U; Alexander, ND; Aziz, N; Owens, BM; Kaur, H; Jasseh, M; Muangnoicharoen, S; Sumariwalla, PF; Warhurst, DC; Ward, SA; Conway, DJ; Ulloa, L; Tracey, KJ; Foxwell, BM; Kaye, PM; Walther, M; (2010)

PLoS One, 5 (4). e9867. ISSN 1932-6203 DOI: 10.1371/journal.pone.0009867

Cairns, M; Gosling, R; Carneiro, I; Gesase, S; Mosha, JF; Hashim, R; Kaur, H; Lemnge, M; Mosha, FW; Greenwood, B; Chandramohan, D; (2010)

PLoS One, 5 (3). e9467. ISSN 1932-6203 DOI: 10.1371/journal.pone.0009467

Kaur, H; Green, MD; Hostetler, DM; Fernáández, FM; Newton, PN; (2010)

Therapy, 7. pp. 49-57. ISSN 1475-0708 DOI: 10.2217/thy.09.84

Oxborough, RM; Weir, V; Irish, S; Kaur, H; N'guessan, R; Boko, P; Odjo, A; Metonnou, C; Yates, A; Akogbeto, M; Rowland, MW; (2009)

Acta tropica, 112 (1). pp. 49-53. ISSN 0001-706X DOI: 10.1016/j.actatropica.2009.06.005

Rodriguez, M; Perez, L; Caicedo, JC; Prieto, G; Arroyo, JA; Kaur, H; Suarez-Mutis, M; de la Iioz, F; Lines, J; Alexander, N; (2009)

Journal of medical entomology, 46 (2). pp. 307-315. ISSN 0022-2585 DOI: 10.1603/033.046.0215

Onwujekwe, O; Kaur, H; Dike, N; Shu, E; Uzochukwu, B; Hanson, K; Okoye, V; Okonkwo, P; (2009)

Malar J, 8. p. 22. ISSN 1475-2875 DOI: 10.1186/1475-2875-8-22

Leslie, T; Kaur, H; Mohammed, N; Kolaczinski, K; Ord, RL; Rowland, M; (2009)

Emerging infectious diseases, 15 (11). pp. 1753-9. ISSN 1080-6040 DOI: 10.3201/eid1511.090886

Ioset, JR; Kaur, H; (2009)

PLoS One, 4 (9). e7270. ISSN 1932-6203 DOI: 10.1371/journal.pone.0007270

Newton, PN; Lee, SJ; Goodman, C; Fernandez, FM; Yeung, S; Phanouvong, S; Kaur, H; Amin, AA; Whitty, CJM; Kokwaro, GO; Lindegardh, N; Lukulay, P; White, LJ; Day, NPJ; Green, MD; White, NJ; (2009)

PLoS medicine, 6 (3). ISSN 1549-1277 DOI: 10.1371/journal.pmed.1000052

Kayedi, MH; Kaur, H; Haghdoost, AA; Lines, JD; (2009)

Annals of tropical medicine and parasitology, 103 (1). pp. 85-90. ISSN 0003-4983 DOI: 10.1179/136485909X385018

Kaur, H; Eggelte, T; (2009)

Taylor, MC; Kaur, H; Blessington, B; Kelly, JM; Wilkinson, SR; (2008)

The Biochemical journal, 409 (2). pp. 563-9. ISSN 0264-6021 DOI: 10.1042/BJ20071185

Kaur, H; Goodman, C; Thompson, E; Thompson, KA; Masanja, I; Kachur, SP; Abdulla, S; (2008)

PLoS One, 3 (10). e3403. ISSN 1932-6203 DOI: 10.1371/journal.pone.0003403

Logan, FJ; Taylor, MC; Wilkinson, SR; Kaur, H; Kelly, JM; (2007)

The Biochemical journal, 407 (3). pp. 419-26. ISSN 0264-6021 DOI: 10.1042/BJ20070766

Kaur, H; Ioset, J.-, R; (2007)

ASSAY, KIT AND APPARATUS FOR DETECTION OF ARTEMISININ DERIVATIVES.

Kaur, H; Goodman, C; Masanja, I; Thompson, E; Thompson, KA; Kachur, SP; (2007)

Newton, PN; McGready, R; Fernandez, F; Green, MD; Sunjio, M; Bruneton, C; Phanouvong, S; Millet, P; Whitty, CJ; Talisuna, AO; Proux, S; Christophel, EM; Malenga, G; Singhasivanon, P; Bojang, K; Kaur, H; Palmer, K; Day, NP; Greenwood, BM; Nosten, F; White, NJ; (2006)

PLoS medicine, 3 (6). 752-755 . ISSN 1549-1277 DOI: 10.1371/journal.pmed.0030197

Graham, K; Kayedi, MH; Maxwell, C; Kaur, H; Rehman, H; Malima, R; Curtis, CF; Lines, JD; Rowland, MW; (2005)

Medical and veterinary entomology, 19 (1). pp. 72-83. ISSN 0269-283X DOI: 10.1111/j.0269-283X.2005.00543.x

Yates, A; N'guessan, R; Kaur, H; Akogbeto, M; Rowland, M; (2005)

Malar J, 4. p. 52. ISSN 1475-2875 DOI: 10.1186/1475-2875-4-52

Cutts, FT; Zaman, A; Enwere, G; Biney, E; Akano, A; Kaur, H; Olulwalana, C; Vaughan, A; Okoko, B; Adegbola, R; Levine, O; Greenwood, B; (2004)

McGorum, BC; Wilson, R; Pirie, RS; Mayhew, IG; Kaur, H; Aruoma, OI; (2003)

Equine veterinary journal, 35 (2). pp. 121-126. ISSN 0425-1644 DOI: 10.2746/042516403776114225

Kaur, H; Hughes, MN; Naughton, P; Green, CJ; Foresti, R; Motterlini, R; (2003)

FEBS letters, 543. pp. 113-119. ISSN 0014-5793 DOI: 10.1016/S0014-5793(03)00420-4

Kaur, H; (2003)

In: Bahorun, T; Gurib-Fakim, A, (eds.) Molecular and Therapeutic Aspects of Redox Biochemistry. OICA International, London, pp. 127-144.

Kaur, H; Rakhit, D; Davies, S; (2003)

Kaur, H; (2002)

Kaur, H; (2001)

Who we are

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Harparkash Kaur set up the bioanalytical facility as part of the Gates Malaria Partnership in 2001, and from 2008 was lead investigator on the drug quality project for the ACT Consortium.

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To support us, please contact us:

Address: Keppel Street, London WC1E 7HT
Phone: 0207 299 4629
Email: Harparkash.kaur@lshtm.ac.uk

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London School of Hygiene & Tropical Medicine